Episode 37 - Oh no, it rhymes!

In this episode, we’re talking about the OAS-RNaseL virus-sensing pathway, and the passage of its product, 2,5-oligoadenylate, through gap junctions.

Also in this episode, Matt relives his gel-running trauma, Kate remembers getting scooped, and Kevin still can’t figure out his terrible, horrible, no good, very bad internet.

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Links

• The paper - OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity

• The beautiful cGAS and cGAMP papers Kate is constantly referencing.