Matt and Kevin take a humbling look back a classic 1989 immunology paper from the lab of David Baltimore (RIP) in which the gene encoding RAG-1, one of two genes that is responsible for the VDJ recombination - a mechanism for the generation of diversity in the adaptive immune system.
But most of this conversation is about the wildly complicated molecular biology they had to use in 1989.
Links
The Paper: The V(D)J recombinase activating gene, RAG-1
Previous audiommunity episode on VDJ recombination: Antibodies and Infantry
TWiV Episode 100 - podcast interviewing Baltimore about his life and career
David Baltimore Nobel Lecture
